Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Incidence of Early and In-hospital Late Seizures Following Aneurysmal Subarachnoid Hemorrhage in Patients Treated with Clazosentan: A Multicenter Retrospective Cohort Study.

Neurologia medico-chirurgica·2026
Same author

Reconsidering Surgical Intervention for Infection After Cranioplasty in Older Adults: A Case Report.

Cureus·2026
Same author

Electroencephalogram-based Objective Assessment of Surgical Expertise during Microvascular Anastomosis Training.

Neurologia medico-chirurgica·2026
Same author

Factors Associated With Unexpected Movement During Transcranial Electrical Stimulation-Motor Evoked Potential Monitoring for Neurosurgical and Neuroendovascular Procedures: A Propensity-weighted Study.

Journal of neurosurgical anesthesiology·2026
Same author

How Often Is Enough? Training Frequency Required to Maintain Microsurgical Anastomosis Skills: A Longitudinal Analysis of Self-Practice Records.

Neurosurgery practice·2026
Same author

Incidental Detection of a Small, Non-spiculated Breast Cancer During Preoperative Evaluation for an Unruptured Cerebral Aneurysm With Gradual Enlargement Over 16 Years: A Case Report.

Cureus·2026

Related Experiment Video

Updated: Aug 2, 2025

The Helsinki Rat Microsurgical Sidewall Aneurysm Model
13:53

The Helsinki Rat Microsurgical Sidewall Aneurysm Model

Published on: October 12, 2014

12.3K

Computational Fluid Dynamics Analysis Features in Aneurysm Development in Rats.

Shoichi Komura1, Katsuya Komatsu1, Takeshi Mikami1

  • 1Department of Neurosurgery, Sapporo Medical University.

Neurologia Medico-Chirurgica
|April 21, 2023
PubMed
Summary
This summary is machine-generated.

Cerebral aneurysm development is linked to changes in blood vessel shape, including increased diameter and curvature, and reduced wall shear stress (WSS). This study used an animal model to clarify computational fluid dynamics (CFD) findings.

Keywords:
animal aneurysm modelcomputational fluid dynamicsdolichoectatic aneurysmlow WSS

More Related Videos

Microsurgical Creation of Giant Bifurcation Aneurysms in Rabbits for the Evaluation of Endovascular Devices
07:21

Microsurgical Creation of Giant Bifurcation Aneurysms in Rabbits for the Evaluation of Endovascular Devices

Published on: September 8, 2023

763
Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit
07:04

Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit

Published on: April 15, 2021

2.2K

Related Experiment Videos

Last Updated: Aug 2, 2025

The Helsinki Rat Microsurgical Sidewall Aneurysm Model
13:53

The Helsinki Rat Microsurgical Sidewall Aneurysm Model

Published on: October 12, 2014

12.3K
Microsurgical Creation of Giant Bifurcation Aneurysms in Rabbits for the Evaluation of Endovascular Devices
07:21

Microsurgical Creation of Giant Bifurcation Aneurysms in Rabbits for the Evaluation of Endovascular Devices

Published on: September 8, 2023

763
Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit
07:04

Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit

Published on: April 15, 2021

2.2K

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Neurosurgery

Background:

  • Cerebral aneurysms pose a risk for subarachnoid hemorrhage.
  • Computational fluid dynamics (CFD) analysis has been used to study aneurysm development, but results lack unified interpretation.
  • Understanding CFD characteristics is crucial for predicting and preventing aneurysm growth.

Purpose of the Study:

  • To clarify CFD analysis results associated with cerebral aneurysm development.
  • To investigate the relationship between vascular morphology and hemodynamic factors in aneurysm formation using an animal model.

Main Methods:

  • Nineteen rat models of cerebral aneurysms were created.
  • CFD analysis was performed and compared between an aneurysm group (n=10) and a non-aneurysm group (n=9).
  • Vascular morphology (cross-sectional area, curvature) and wall shear stress (WSS) were evaluated in the left cerebral artery (P1).

Main Results:

  • The aneurysm group showed decreased WSS at the aneurysm site compared to the non-aneurysm group.
  • Increased cross-sectional area and higher mean curvature of the left P1 were observed in the aneurysm group.
  • Aneurysm development correlated with increased vessel diameter, high curvature, and reduced WSS.

Conclusions:

  • Cerebral aneurysm development is associated with alterations in vascular morphology, specifically increased vessel diameter and curvature.
  • Reduced WSS at specific locations is a key factor in cerebral aneurysm development.
  • This animal model provides insights into the hemodynamic and morphological changes underlying aneurysm formation.