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Related Experiment Video

Updated: Aug 2, 2025

Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue

Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue

Published on: January 6, 2012

Decrease in CD226 expression on CD4⁺ T cells in patients with endometriosis.

Cui Li¹, Jing Zhou², Jun Shao³

¹Clinical Laboratory Department, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Bioscience Trends

|April 21, 2023

Summary

This summary is machine-generated.

Endometriosis is linked to lower CD226 levels on CD4+ T cells. This reduction correlates with T cell effector function, suggesting CD226 blockade may suppress disease activity in endometriosis patients.

Keywords:

CD226 CD4+ T cells TIGIT endometriosis

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Published on: December 21, 2012

Area of Science:

Immunology
Cell Biology
Reproductive Medicine

Background:

Endometriosis is a chronic inflammatory condition.
Immune-checkpoint molecules CD226 and TIGIT regulate T cell function.
The role of CD226 and TIGIT on CD4+ T cells in endometriosis remains unclear.

Purpose of the Study:

To investigate the proportion and function of CD226 and TIGIT on CD4+ T cells in endometriosis.
To determine the correlation between CD226/TIGIT expression and cytokine profiles.
To assess the impact of blocking CD226 and TIGIT on T cell function.

Main Methods:

Flow cytometry analysis of CD4+ T cells.
Quantification of TIGIT and CD226 expression.
Measurement of cytokine levels (TNF-α, IL-10, IFN-γ).
Functional assays involving TIGIT and CD226 blockade.

Main Results:

CD226 levels were significantly lower on CD4+ T cells in endometriosis patients compared to controls.
TIGIT expression on CD4+ T cells showed no significant difference between groups.
Both TIGIT+ and CD226+ CD4+ T cells exhibited elevated levels of TNF-α, IL-10, and IFN-γ.
Blocking CD226 reduced TNF-α and IFN-γ while increasing IL-10, suggesting modulation of effector function.

Conclusions:

Endometriosis is associated with a diminished CD226 expression on CD4+ T cells.
This reduction in CD226 correlates with CD4+ T cell effector functions.
Targeting CD226 may represent a potential therapeutic strategy for endometriosis.