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Rustrela Virus as Putative Cause of Nonsuppurative Meningoencephalitis in Lions

Madeleine de le Roi, Christina Puff, Peter Wohlsein

    Emerging Infectious Diseases
    |April 21, 2023
    PubMed

    Abstract:

    Retrospective investigation of archived tissue samples from 3 lions displaying nonsuppurative meningoencephalitis and vasculitis led to the detection of rustrela virus (RusV). We confirmed RusV antigen and RNA in cortical neurons, axons, astrocytes and Purkinje cells by reverse transcription quantitative PCR, immunohistochemistry, and in situ hybridization.

    Keywords:
    Baumgärtner WBeer MGermanyPfaff FPuff CRubivirusRubivirus strelenseSuggested citation for this article: de le Roi MWohlsein Pet al. Rustrela virus as putative cause of nonsuppurative meningoencephalitis in lions. Emerg Infect Dis. 2023 May [date cited]. https://doi.org/10.3201/eid2905.230172lionsmeningitis/encephalitismeningoencephalitisretrospective studyrustrela virusviruses

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