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Allergen Sensitization in Children in Weifang, China: Differences Between Monosensitization and Polysensitization
Xiyan Zhang1,2, Hui Chen1, Shengnan Liu3
1School of Clinical Medicine, Weifang Medical University, Weifang, People's Republic of China.
Insights
Children with allergies are more likely to be sensitized to multiple allergens, leading to higher immunoglobulin E (IgE) levels and eosinophil counts. Understanding these patterns is key for managing childhood allergic diseases.
Area of Science:
- Pediatric Allergy and Immunology
- Clinical Immunology
- Environmental Allergens
Background:
- Children exhibit the highest prevalence of allergy diseases globally.
- Limited understanding exists regarding monosensitization and polysensitization patterns in pediatric populations.
- This study investigates allergen sensitization in children from Weifang, China.
Purpose of the Study:
- To characterize monosensitization and polysensitization in children.
- To identify differences in intrinsic and clinical parameters between monosensitized and polysensitized children.
Main Methods:
- Analysis of 6030 individuals requiring allergy testing.
- Inclusion of 938 children (1 month–18 years) with positive allergen tests (15 common allergens).
- Comparison of intrinsic features (age, gender, specific IgE, total IgE) and clinical parameters (eosinophil and basophil counts/percentages).
Main Results:
- Most prevalent allergens in monosensitized children: dust mites, molds, tree/grass pollens.
- Common polysensitization patterns: dust mites with molds, Artemisia, or Humulus scandens pollens.
- Polysensitization correlated with elevated specific IgE, total IgE, and eosinophil levels.
Conclusions:
- Provides an overview of allergen profiles in monosensitized and polysensitized children.
- Highlights the impact of polysensitization on allergic disease severity.
- Offers insights for improved management strategies for pediatric allergic diseases.
Background:
Children are the age group with the highest prevalence of allergy diseases. There is currently a lack of knowledge regarding monosensitization and polysensitization characteristics in children. In this study, we investigated the characteristics and differences between monosensitization and polysensitization in children in Weifang, eastern China.
Objective:
To demonstrate the basic features of monosensitization and polysensitization in children. To explore the inherent and clinical parameter differences between monosensitized and polysensitized children.
Material And Methods:
A total of 6030 individuals with a physician-determined need for allergy testing were tested for 15 common allergens, including 9 aeroallergens and 6 food allergens. A total of 938 allergen-positive children aged 1 month to 18 years were eventually included in this analysis. Complete blood count results from the same time as the allergen test were derived from the computerized medical records. Intrinsic features such as age, gender, sIgE, T-IgE, and clinical parameters such as eosinophil percentage, eosinophil count, basophil percentage, and basophil count were compared.
Results:
The results showed that dust mite-related allergens, mould-related allergens, and tree and grass pollen-related allergens were the most prevalent allergens among monosensitized children. Additionally, the results of the combined pattern of polysensitive childhood allergens indicate the most common two allergens that were present together included dust mites and mould-related allergens, dust mite and Artemisia pollens, and dust mite and Humulus scandens pollens. Polysensitization can result in higher sIgE, T-IgE and eosinophil levels.
Conclusion:
In conclusion, we provide a basic overview of allergens in monosensitized and polysensitized children. These findings provide new insight into the management of allergic diseases, particularly from the standpoint of polysensitization.
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