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The Spectrum of COVID-19-Induced Liver Injury in Various Age and Risk Groups

Tapasya Bhusal1, Prakash Banjade2, Salim Surani3,4,5,6

  • 1General Medicine, Shahid Dharmabhakta National Transplant Center, Kathmandu, NPL.

Cureus
|April 21, 2023
PubMed

Insights

Coronavirus disease 2019 (COVID-19) can cause liver injury across various patient groups. This review examines COVID-19-related liver damage, focusing on risk factors, biomarkers, and management strategies.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Internal Medicine

Background:

  • Coronavirus disease 2019 (COVID-19) has caused widespread illness and death globally.
  • While primarily respiratory, COVID-19 impacts multiple organ systems, including the liver.
  • Existing literature on COVID-19 liver injury needs further stratification by age and risk factors.

Purpose of the Study:

  • To comprehensively review liver injury associated with COVID-19.
  • To analyze COVID-19-related liver damage in diverse age and risk demographics.
  • To explore the pathophysiology, biochemical markers, outcomes, and management of liver injury in COVID-19 patients.

Main Methods:

  • Literature review and synthesis of existing research on COVID-19 and liver injury.
  • Analysis of studies stratifying liver injury by patient age and risk factors.
  • Discussion of pathophysiological mechanisms, diagnostic markers, and therapeutic approaches.

Main Results:

  • COVID-19 can manifest with varying degrees of liver injury.
  • Specific age and risk groups may exhibit distinct patterns of liver involvement.
  • Biochemical markers of liver injury correlate with disease severity and patient outcomes.

Conclusions:

  • Liver injury is a significant multisystem complication of COVID-19.
  • Understanding demographic-specific liver injury is crucial for effective management.
  • Further research into pathophysiology and targeted therapies for COVID-19-related liver injury is warranted.

Keywords:
alanine transaminaseaspartate transaminasecoronavirus disease-2019liver diseaseliver enzymesars-cov-2 infection liver injury in covid-19

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