Aggregation-Induced Emission Macromolecular Materials for Antibacterial Applications.
Yunfei Zuo1, Ryan T K Kwok1, Jianwei Sun1
1Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, and Division of Life Science, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 999077, P.R. China.
Macromolecular Rapid Communications
|April 21, 2023
Summary
Aggregation-induced emission (AIE) macromolecular materials show promise for fighting multidrug-resistant bacterial infections and biofilms. This review covers AIE polymers, AIEgen@polymer complexes, and CTE polymers for antibacterial applications.
Area of Science:
- Polymer Science
- Materials Science
- Biomedical Engineering
Background:
- Multidrug-resistant infections and bacterial biofilms pose significant health challenges.
- Aggregation-induced emission (AIE) macromolecular materials offer novel antibacterial strategies.
- These materials enable real-time bacterial monitoring and targeted therapies.
Purpose of the Study:
- To review the current state of AIE macromolecular materials with antibacterial properties.
- To categorize and discuss different types of AIE-based antibacterial agents.
- To highlight their mechanisms, applications, and future potential.
Main Methods:
- Literature review of AIE macromolecular materials for antibacterial applications.
- Categorization based on material type: AIE-active polymers, AIEgen@polymer complexes, and clusterization-triggered emission (CTE) based polymers.
- Discussion of mechanisms, antibacterial treatment, wound care, and protective equipment.
Main Results:
- AIE macromolecular materials are classified into three main categories.
- These materials demonstrate potential in combating bacterial infections, including biofilms and multidrug-resistant strains.
- Applications span antibacterial treatments, advanced wound care, and protective equipment.
Conclusions:
- AIE macromolecular materials represent a promising frontier in antimicrobial development.
- Further research can unlock their full potential in addressing critical infectious diseases.
- Future directions include enhanced targeting, therapeutic efficacy, and broader application scope.
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