Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

401
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
401
Long-term Depression01:03

Long-term Depression

2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nucleus-level thalamic organization anchors multimodal signatures of thalamocortical maturation.

bioRxiv : the preprint server for biology·2026
Same author

Complementary predictive value of electromagnetic source imaging and hemodynamic responses in epilepsy surgery: A quantitative spatial analysis.

Epilepsia·2026
Same author

An open dataset of cerebral tau deposition in young healthy adults based on [<sup>18</sup>F]MK6240 positron emission tomography.

Scientific data·2026
Same author

Multiscale characterization of the human claustrum from histology to MRI.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Sex-related structural alterations across common epilepsies: a worldwide ENIGMA study.

bioRxiv : the preprint server for biology·2026
Same author

Rethinking cortical hypertrophy in temporal lobe epilepsy.

Brain : a journal of neurology·2026

Related Experiment Video

Updated: Aug 2, 2025

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.1K

Cortical microstructural gradients capture memory network reorganization in temporal lobe epilepsy.

Jessica Royer1,2, Sara Larivière1, Raul Rodriguez-Cruces1

  • 1Multimodal Imaging and Connectome Analysis Laboratory, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC H3A 2B4, Canada.

Brain : a Journal of Neurology
|April 21, 2023
PubMed
Summary

Temporal lobe epilepsy (TLE) causes brain changes, reducing differences between brain regions. This impacts memory and quality of life for patients.

Keywords:
epilepsymemorymicrostructureneuroimagingstructure-function

More Related Videos

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.5K
Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue
13:14

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue

Published on: October 26, 2014

20.8K

Related Experiment Videos

Last Updated: Aug 2, 2025

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.1K
Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.5K
Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue
13:14

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue

Published on: October 26, 2014

20.8K

Area of Science:

  • Neuroscience
  • Neuroimaging
  • Epilepsy Research

Background:

  • Temporal lobe epilepsy (TLE) is a common, drug-resistant epilepsy linked to paralimbic region pathology.
  • Cognitive dysfunction, especially episodic memory impairment, significantly affects TLE patients' quality of life.

Purpose of the Study:

  • To investigate the neural basis of cognitive dysfunction in TLE using advanced MRI.
  • To assess cortex-wide microstructural differentiation gradients and their reorganization in TLE.

Main Methods:

  • High-resolution MRI was used to analyze spatial gradients of microstructural differentiation in 21 TLE patients and 35 controls.
  • Findings were validated in an independent cohort and correlated with post-mortem cytoarchitecture and transcriptomics.
  • Episodic memory functional MRI (fMRI) was employed to assess cognitive network reorganization.

Main Results:

  • TLE patients showed reorganized microstructural gradients, with reduced differentiation between paralimbic and other cortical areas.
  • Abnormalities were noted in temporopolar and dorsolateral prefrontal regions, consistent with cytoarchitectural data.
  • Microstructural dedifferentiation correlated with functional network reorganization and episodic memory task performance.

Conclusions:

  • Reduced microarchitectural differentiation in TLE provides a structural basis for cognitive dysfunction.
  • Findings highlight a pattern of cortical reorganization impacting paralimbic and widespread brain networks.
  • This research offers insights into improving patient management for TLE-related cognitive deficits.