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Targeting neddylation as a novel approach to lung cancer treatment (Review)
Zhaochun Tian1, Jiafei Li2, Ruijie Ma3
1Science and Technology Innovation Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250117, P.R. China.
Abstract:
As a protein that resembles ubiquitin, neural precursor cell expressed developmentally downregulated 8 (NEDD8) takes part in neddylation, which modifies substrates in a manner similar to ubiquitination and alters the activity of target proteins. Neddylation may affect the activity of multiple signaling pathways, have a regulatory role in tumor formation, progression and metastasis, and influence the prognosis of cancer treatment. The present review summarizes the regulatory roles of NEDD8 in the MDM2‑p53, NF‑κB, PI3K/AKT/mTOR, hypoxia‑inducible factor, Hippo and receptor tyrosine kinase signaling pathways, as well as in the development and progression of lung cancer.
Insights
Neural precursor cell expressed developmentally downregulated 8 (NEDD8) protein regulates key cancer pathways. This review explores NEDD8
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Neural precursor cell expressed developmentally downregulated 8 (NEDD8) is a ubiquitin-like protein crucial for neddylation.
- Neddylation modifies protein activity, impacting cellular processes and disease.
- Dysregulated neddylation is implicated in cancer development and progression.
Approach:
- This review synthesizes current research on NEDD8's role in cancer.
- It examines NEDD8's involvement in critical signaling pathways.
- The focus is on lung cancer development and progression.
Key Points:
- NEDD8 influences the MDM2-p53, NF-κB, PI3K/AKT/mTOR, HIF, Hippo, and RTK signaling pathways.
- Neddylation impacts tumor formation, progression, and metastasis.
- NEDD8 activity affects cancer treatment prognosis.
Conclusions:
- NEDD8 plays a significant regulatory role in multiple cancer-associated signaling pathways.
- Understanding NEDD8's function is vital for targeting lung cancer.
- Further research into NEDD8 could reveal new therapeutic strategies for cancer treatment.
