One-Insertion Stereotactic Brain Biopsy Using In Vivo Optical Guidance-A Case Study
Karin Wårdell1, Elisabeth Klint1, Peter Milos2
1Department of Biomedical Engineering, Linköping University, Linköping, Sweden.
Operative Neurosurgery (Hagerstown, Md.)
|April 21, 2023
Summary
This study introduces a novel 1-insertion stereotactic biopsy kit with optical feedback, improving accuracy and reducing surgical time for brain biopsies. The new method enhances diagnostic yield and patient safety in neurosurgery.
Area of Science:
- Neurosurgery
- Medical Devices
- Biotechnology
Background:
- Stereotactic brain biopsies carry risks of inconclusive results and hemorrhage.
- These complications can lead to repeat procedures and extended surgical duration.
Purpose of the Study:
- To develop and evaluate a 1-insertion stereotactic biopsy kit with intraoperative optical feedback.
- To assess its clinical applicability in three neurosurgical cases.
Main Methods:
- An in-house optical probe was integrated into a biopsy kit for real-time feedback.
- Optical signals and 5-aminolevulinic acid (5-ALA) fluorescence were measured along the trajectory.
- Tissue samples were collected at the site of maximal fluorescence.
Main Results:
- The procedure provided direct visual feedback on 5-ALA fluorescence, microcirculation, and tissue appearance within 5-10 minutes.
- Intraoperative fluorescence correlated with pathology results.
- Single-insertion biopsies reduced overall surgical time.
Conclusions:
- A 1-insertion stereotactic biopsy with real-time optical guidance was successfully applied in three cases.
- This technique has the potential to enhance safety and diagnostic accuracy for stereotactic neurosurgical biopsies.
- The method is adaptable for frameless navigation systems.
