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Clinical Characteristics of Pediatric Patients With Septic Shock Caused by Acute Appendicitis: A Case Series

Fangnan Xie1, Li Wang1, Long Chen1

  • 1From the Departments of Emergency Surgery.

Pediatric Emergency Care
|April 21, 2023
PubMed

Insights

Pediatric septic shock from appendicitis is linked to delayed diagnosis, abnormal weight, high inflammatory markers, and metabolic diseases. These factors increase the risk of severe complications and poor outcomes in children.

Area of Science:

  • Pediatric critical care
  • Infectious diseases
  • Surgical emergencies

Background:

  • Septic shock in children is a life-threatening condition.
  • Acute appendicitis is a common surgical emergency in pediatrics.
  • Understanding risk factors for septic shock in pediatric appendicitis is crucial for timely intervention.

Purpose of the Study:

  • To investigate the clinical features of pediatric septic shock secondary to acute appendicitis.
  • To identify potential risk factors associated with severe outcomes.

Main Methods:

  • A case series was conducted at Beijing Children's Hospital from January 2015 to December 2020.
  • Included patients were pediatric cases of septic shock caused by acute appendicitis.
  • Clinical data, including diagnosis time, inflammatory markers, and comorbidities, were analyzed.

Main Results:

  • Six pediatric patients with septic shock due to appendicitis were identified.
  • Delayed diagnosis (4-5 days) occurred in 4 patients.
  • Elevated inflammatory markers (CRP, procalcitonin), appendix perforation (4/6), and diffused peritonitis (3/6) were common.
  • Two patients had underlying metabolic diseases; one patient died.

Conclusions:

  • Delayed diagnosis, abnormal body weight, significantly elevated inflammatory markers, and underlying metabolic diseases are associated with increased risk.
  • These factors may predict complicated appendicitis and septic shock in children.
  • Early recognition and management are critical for improving outcomes.
Abstract

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