Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stimulants

Stimulants

Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Air pollution and adverse birth outcomes: a narrative review of epidemiological and mechanistic findings.

Journal of environmental health science & engineering·2026

Same author

Multidimensional psychosocial screening in routine cardiac care: preliminary findings from a cross-sectional survey.

Herz·2026

Same author

Nicotine as a cardiovascular drug: haemodynamic stress, oxidative injury, and the regulatory failure to protect the heart.

European heart journal open·2026

Same author

Climate Change and Cardiovascular Health: Advancing Resilient Action Beyond COP30.

Global heart·2026

Same author

Environmental risk factors and cardiovascular health.

European heart journal·2026

Same author

Europe's heat and fire crisis and the new fossil-fuel surge from artificial intelligence.

European heart journal·2026

Same journal

Expression of protein kinase A catalytic subunits in healthy and diseased mouse kidneys.

Pflugers Archiv : European journal of physiology·2026

Same journal

Localization of O₂‑sensing ADO‑RGS pathway components in mouse and human kidneys under normoxia, hypoxia and renal fibrosis.

Pflugers Archiv : European journal of physiology·2026

Same journal

Cholesterol-depleting dextrin depolarizes sarcolemma: the contribution of sodium / calcium channels and membrane integrity.

Pflugers Archiv : European journal of physiology·2026

Same journal

Inhibition of (interstitial) P2Y<sub>6</sub> receptors attenuates fibrosis progression.

Pflugers Archiv : European journal of physiology·2026

Same journal

Renal NHE3 is required to limit hypokalemia and metabolic acidosis during dietary potassium deficiency.

Pflugers Archiv : European journal of physiology·2026

Same journal

Xenin-25 improves indomethacin-induced acute gastric injury in rats.

Pflugers Archiv : European journal of physiology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Aug 2, 2025

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System

Published on: May 24, 2017

E-cigarette effects on vascular function in animals and humans.

Andreas Daiber^1,2, Marin Kuntic^3,4, Matthias Oelze³

¹Department of Cardiology 1, University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, 55131, Mainz, Germany. daiber@uni-mainz.de.

Pflugers Archiv : European Journal of Physiology

|April 21, 2023

Summary

This summary is machine-generated.

E-cigarette vaping and tobacco smoking pose similar cardiovascular risks due to shared toxic compounds that impair endothelial function. Both habits may lead to addiction and vascular damage, challenging the notion of e-cigarettes as a safer alternative.

Keywords:

E-cigarette vaping Endothelial dysfunction Inflammation Oxidative stress Tobacco cigarettes

More Related Videos

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies

Published on: August 25, 2018

A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol

A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol

Published on: January 18, 2018

Related Experiment Videos

Last Updated: Aug 2, 2025

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System

Published on: May 24, 2017

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies

Published on: August 25, 2018

A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol

A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol

Published on: January 18, 2018

Area of Science:

Cardiovascular Health
Toxicology
Public Health

Background:

Tobacco cigarette smoking is a major cardiovascular risk factor.
Shisha and e-cigarette use have risen, potentially offsetting declines in cigarette smoking.
E-cigarettes may lead to dual use (vaping and smoking) and nicotine addiction.

Purpose of the Study:

To review the adverse health impacts of tobacco cigarettes and e-cigarettes.
To emphasize the detrimental effects on endothelial function and cardiovascular health.

Main Methods:

Review of existing literature on tobacco and e-cigarette health effects.
Comparison of toxic compound overlap and pathomechanistic features.
Focus on endothelial dysfunction and oxidative stress.

Main Results:

E-cigarette vaping causes oxidative stress, inflammation, and endothelial dysfunction, similar to smoking.
Toxic compounds in e-cigarette vapor and tobacco smoke largely overlap, leading to similar cardiovascular risks.
E-cigarettes may not aid smoking cessation and could promote earlier nicotine addiction.

Conclusions:

E-cigarettes are not a healthier alternative to tobacco smoking and pose significant cardiovascular risks.
Oxidative stress is a key mechanism mediating endothelial dysfunction in both vaping and smoking.
Public health strategies should address the risks associated with both traditional and novel nicotine products.