Related Experiment Video
Updated: Aug 2, 2025

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
Reactive arthritis after COVID-19 vaccination: 17 cases
Marc Alexandre Golstein1, Olivier Fagnart2, Serge Daniel Steinfeld1
1Department of Rheumatology, Saint-Jean Hospital, Brussels, Belgium.
Objectives:
The aim of the study is to report a series of 17 cases of ankle bi-arthritis that occurred shortly after coronavirus disease 2019 RNA vaccination, and to discuss the potential role of these vaccines in the pathogenesis of this rheumatological manifestation.
Methods:
All patients were examined in the same department and received a full work-up to investigate the usual causes of ankle bi-arthritis. No rheumatic inflammatory disease occurred after 9 months of follow-up. A post-vaccination serological follow-up in search of anti-Spike antibodies was requested for all patients.
Results:
All patients recovered with low dose of prednisolone within <2 months, except one who could not be weaned off CS. The level of antibodies found was very high in all patients.
Conclusion:
The ankle bi-arthritis occurrence chronology, the follow-up and the similar clinical presentation might suggest a pathogenic role of RNA vaccination.
Related Concept Videos
Rheumatic Heart Disease I: Introduction
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Allergic Reactions
Myocarditis II: Clinical Features and Diagnostic Tests
Pericarditis I: Introduction
Myocarditis III: Medical Management

