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Elevated neutrophil-related immune-inflammatory biomarkers in acute anterior choroidal artery territory infarction

Ning Zhao1, Jia Li1, Qiu-Xia Zhang1

  • 1Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.

Clinical Neurology and Neurosurgery
|April 21, 2023
PubMed

Insights

Neutrophil to high-density lipoprotein cholesterol ratio (NHR) and neutrophil to lymphocyte ratio (NLR) can predict early progression in acute anterior choroidal artery infarction. Combining NHR and NLR may offer a better prognostic marker for this condition.

Area of Science:

  • Neurology
  • Biomarkers
  • Stroke Research

Background:

  • Anterior choroidal artery (AChA) territory infarction is associated with rapid progression and poor functional outcomes.
  • Identifying early predictive biomarkers for AChA infarction progression is crucial for timely intervention.

Purpose of the Study:

  • To identify fast and convenient biomarkers for forecasting the early progression of acute AChA infarction.
  • To evaluate the discriminant efficacy of various laboratory indices in predicting AChA infarction progression.

Main Methods:

  • A cohort of 51 acute AChA infarction patients was analyzed.
  • Laboratory indices were compared between early progressive and non-progressive groups.
  • Receiver-operating characteristic (ROC) curve analysis was employed to assess predictive accuracy.

Main Results:

  • Neutrophil to high-density lipoprotein cholesterol ratio (NHR) and neutrophil to lymphocyte ratio (NLR) were significantly higher in progressive AChA infarction.
  • ROC analysis indicated that NHR and NLR, individually and combined, showed discriminant efficacy in predicting progression.
  • The combined NHR and NLR demonstrated a promising area under the ROC curve of 0.751.

Conclusions:

  • NHR and NLR may serve as significant predictors for early progressive acute AChA infarction.
  • The combination of NHR and NLR could be a valuable prognostic marker for patients with an early progressive course of AChA infarction.
Abstract

Keywords:
Anterior choroidal arteryEarly progressionInfarctionNeutrophil to high-density lipoprotein cholesterol ratioNeutrophil to lymphocyte ratio

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