Related Experiment Video

Updated: Aug 2, 2025

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

Published on: August 21, 2016

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Genome-wide cross-trait analysis and Mendelian randomization reveal a shared genetic etiology and causality between

Xin Huang1, Minhao Yao2, Peixin Tian2

  • 1School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.

Communications Biology
|April 21, 2023
PubMed

Insights

COVID-19 and venous thromboembolism (VTE) share genetic links, particularly involving genes related to blood clotting. This research clarifies the genetic basis, aiding in understanding and managing these interconnected conditions.

Area of Science:

  • Genetics
  • Immunology
  • Epidemiology

Background:

  • Venous thromboembolism (VTE) affects up to one-third of COVID-19 patients.
  • The shared genetic basis between VTE and COVID-19 remains unclear.

Purpose of the Study:

  • To investigate the shared genetic etiology and causal relationship between COVID-19 and VTE.
  • To identify specific genetic loci and biological pathways involved.

Main Methods:

  • Utilized summary-level genetic data from the COVID-19 Host Genetics Consortium and UK Biobank.
  • Employed cross-trait and co-localization analyses, enrichment analysis, and bi-directional Mendelian randomization.

Main Results:

  • Identified shared genetic loci (ABO, ADAMTS13, FUT2) associated with coagulation functions.
  • Found shared biological processes related to coagulation and immunity.
  • Established bi-directional causal links between VTE and COVID-19 traits, and SARS-CoV-2 infection and VTE.

Conclusions:

  • Provides evidence for a shared genetic etiology between COVID-19 and VTE.
  • Enhances understanding of the underlying mechanisms of COVID-19 and VTE.
  • Offers insights for the prevention and comorbidity management of COVID-19.

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