Related Experiment Video
Updated: Aug 2, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
A novel role of DOT1L in kidney diseases
Wei Wei1, Yibo Zhao1, Yanfen Chai1
1Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, 300052, People's Republic of China.
Background:
We systematically summarized the structure and biological function of DOT1L in detail, and further discussed the role of DOT1L in kidney diseases through different mechanisms.
Methods And Results:
We first described the role of DOT1L in various kidney diseases including AKI, CKD, DN and kidney tumor diseases.
Conclusions:
A better understanding of DOT1L as a histone methylase based on characteristics of regulating telomere silencing, transcriptional extension, DNA damage repair and cell cycle could lead to the development of new therapeutic targets for various kidney diseases, thereby improving the prognosis of kidney disease patients.
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