Related Experiment Video

Updated: Aug 2, 2025

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.7K

A concise review on miRNAs as regulators of colon cancer stem cells and associated signalling pathways

Antara Banerjee1, Dikshita Deka2, Makalakshmi Muralikumar2

  • 1Department of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), 603103, Kelambakkam, Chennai, India. antara.banerjee27@gmail.com.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|April 22, 2023
PubMed

Insights

MicroRNAs (miRNAs) are crucial in colon cancer progression and chemoresistance. Targeting miRNAs offers a promising strategy for developing effective colon cancer theranostics and eradicating cancer stem cells.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Colon cancer remains a leading cause of death despite therapeutic advances.
  • Cancer stem cells (CSCs) drive tumor progression, metastasis, and chemoresistance in colon cancer.
  • The tumor microenvironment, including stromal cells, influences cancer development.

Purpose of the Study:

  • To review the role of microRNAs (miRNAs) in colon cancer, focusing on their regulatory mechanisms in cancer cells and CSCs.
  • To explore the potential of miRNAs in theranostics and personalized medicine for colon cancer.
  • To discuss strategies for regulating miRNAs to improve clinical outcomes and develop novel colon cancer treatments.

Main Methods:

  • Literature review of miRNA history, mechanisms, and roles in colon cancer.
  • Analysis of miRNA involvement in tumor growth, apoptosis, and CSCs.
  • Review of current theranostic approaches utilizing miRNAs for colorectal cancer.

Main Results:

  • miRNAs play a significant role in regulating colon cancer cell and CSC behavior.
  • miRNAs are implicated in tumor progression, metastasis, apoptosis, and chemoresistance.
  • miRNAs show potential as diagnostic and therapeutic targets in colorectal cancer theranostics.

Conclusions:

  • A comprehensive understanding of miRNA regulatory roles is essential for effective colon cancer treatment strategies.
  • miRNA-based theranostics offer prospects for eradicating CSCs and enhancing treatment outcomes.
  • Future research should focus on translating miRNA discoveries into clinical applications for colon cancer therapy.
Keywords:
Cancer stem cellsColon cancerTargeted therapyTheranosticmiRNA

More Related Videos

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres06:52

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

6.6K
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

5.5K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.7K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K