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Related Concept Videos

Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Alzheimer's Disease: Overview01:26

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Pathophysiology of Diabetes01:20

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Related Experiment Video

Updated: Aug 2, 2025

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
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Pathophysiological Links Between Obesity and Dementia.

David E Wong Zhang1, Vivian Tran1, Antony Vinh1

  • 1Department of Microbiology, Anatomy, Physiology and Pharmacology, Centre for Cardiovascular Biology and Disease Research, La Trobe University, Bundoora, VIC, 3086, Australia.

Neuromolecular Medicine
|April 22, 2023
PubMed
Summary

Obesity is linked to cognitive decline and dementia. This review explores how the gut-brain axis and systemic inflammation in obesity may contribute to dementia development.

Keywords:
Cognitive functionDementiaGut-brain axisInflammationObesity

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Area of Science:

  • Neuroscience
  • Metabolic disorders
  • Public health

Background:

  • Rising global obesity rates are linked to processed foods and sedentary lifestyles.
  • Obesity is increasingly associated with cognitive impairment and dementia.
  • Mechanisms linking obesity to brain dysfunction require further elucidation.

Purpose of the Study:

  • To review the pathological changes in the brain associated with obesity.
  • To explore the roles of the gut-brain axis and systemic inflammation in obesity-related dementia.

Main Methods:

  • Literature review of existing research on obesity, the gut-brain axis, systemic inflammation, and dementia.
  • Analysis of pathological mechanisms connecting metabolic dysfunction to neurodegeneration.

Main Results:

  • Obesity is associated with significant alterations in the gut-brain axis.
  • Systemic inflammation is a key pathological feature of obesity with implications for brain health.
  • These factors represent potential pathways contributing to dementia in obese individuals.

Conclusions:

  • The gut-brain axis and systemic inflammation are critical pathways through which obesity may promote dementia.
  • Further research into these mechanisms is essential for developing preventative and therapeutic strategies.
  • Understanding these links can inform public health approaches to combatting obesity and dementia.