Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Anatomy of the Eyeball

Anatomy of the Eyeball

The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Kinase-Glo luminescent kinase assay for in vitro determination of PKA activity].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology·2012

Same author

Functional characterization of an arrestin gene on insecticide resistance of Culex pipiens pallens.

Parasites & vectors·2012

Same author

MiR-23a inhibits myogenic differentiation through down regulation of fast myosin heavy chain isoforms.

Experimental cell research·2012

Same author

Let-7b inhibits human cancer phenotype by targeting cytochrome P450 epoxygenase 2J2.

PloS one·2012

Same author

Role of IKK/NF-κB signaling in extinction of conditioned place aversion memory in rats.

PloS one·2012

Same author

Inhibition of poly(ADP-ribose) polymerase attenuates acute kidney injury in sodium taurocholate-induced acute pancreatitis in rats.

Pancreas·2012

Search research articles

Related Experiment Video

Updated: Aug 2, 2025

Author Spotlight: Unveiling Neural Coding and Mechanisms of Visual Processing in the Superior Colliculus

Author Spotlight: Unveiling Neural Coding and Mechanisms of Visual Processing in the Superior Colliculus

Published on: April 21, 2023

Mapping visual functions onto molecular cell types in the mouse superior colliculus.

Yuanming Liu¹, Elise L Savier¹, Victor J DePiero¹

¹Department of Biology, University of Virginia, Charlottesville, VA 22904, USA.

|April 22, 2023

Summary

Researchers identified 28 neuron subtypes in the superficial superior colliculus (sSC) using single-cell transcriptomics. A specific inhibitory neuron subtype was found to be direction-selective, revealing a genetic basis for visual processing organization in the sSC.

Keywords:

cell types direction selectivity inhibitory neurons single-cell sequencing superior colliculus two-photon calcium imaging

More Related Videos

Using Looming Visual Stimuli to Evaluate Mouse Vision

Using Looming Visual Stimuli to Evaluate Mouse Vision

Published on: June 13, 2019

Long-range Channelrhodopsin-assisted Circuit Mapping of Inferior Colliculus Neurons with Blue and Red-shifted Channelrhodopsins

Long-range Channelrhodopsin-assisted Circuit Mapping of Inferior Colliculus Neurons with Blue and Red-shifted Channelrhodopsins

Published on: February 7, 2020

Related Experiment Videos

Last Updated: Aug 2, 2025

Author Spotlight: Unveiling Neural Coding and Mechanisms of Visual Processing in the Superior Colliculus

Author Spotlight: Unveiling Neural Coding and Mechanisms of Visual Processing in the Superior Colliculus

Published on: April 21, 2023

Using Looming Visual Stimuli to Evaluate Mouse Vision

Using Looming Visual Stimuli to Evaluate Mouse Vision

Published on: June 13, 2019

Long-range Channelrhodopsin-assisted Circuit Mapping of Inferior Colliculus Neurons with Blue and Red-shifted Channelrhodopsins

Long-range Channelrhodopsin-assisted Circuit Mapping of Inferior Colliculus Neurons with Blue and Red-shifted Channelrhodopsins

Published on: February 7, 2020

Area of Science:

Neuroscience
Molecular Biology
Visual Processing

Background:

The superficial superior colliculus (sSC) is crucial for visual processing and behaviors.
The functional organization and neuronal delegation within the sSC remain poorly understood.

Purpose of the Study:

To identify and characterize neuron subtypes within the adult mouse sSC.
To investigate the relationship between molecular subtypes and functional tuning to visual stimuli.

Main Methods:

Single-cell transcriptomics to identify neuron subtypes and marker genes.
In vivo calcium imaging of sSC neurons during visual stimulation.
Ex vivo transcriptomic mapping of marker genes onto imaged neurons.

Main Results:

Identification of 28 distinct neuron subtypes and their enriched marker genes in the sSC.
Discovery of a specific inhibitory neuron subtype comprising ~50% of direction-selective cells.
Establishment of a multimodal mapping method linking molecular identity to functional activity.

Conclusions:

A genetic logic underlies the functional organization of the sSC, particularly for direction selectivity.
The study provides a comprehensive molecular atlas of sSC neuron subtypes.
The developed methodology facilitates future research into sSC neuron function, connectivity, and development.