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Multicenter Observational Study on Recurrence Patterns and Health Care Resource Utilization in Stage II Cutaneous Melanoma in Spain: Real-world Evidence From the METHEOR Study.

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Related Experiment Video

Updated: Jul 24, 2026

Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma
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[Translated article] Update on Lentigo Maligna: Diagnostic Signs and Treatment.

C Requena1, E Manrique1, E Nagore1

  • 1Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain.

Actas Dermo-Sifiliograficas
|April 22, 2023
PubMed
Summary

Lentigo maligna, a slow-growing melanoma on sun-damaged skin, presents diagnostic and treatment challenges. Early detection and appropriate management are crucial for better patient outcomes.

Keywords:
HistopathologyHistopatologíaLentigo malignaLentigo malignoMohsTratamientoTreatment

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Lentigo maligna is an early-stage melanoma developing on sun-exposed skin, commonly affecting older individuals.
  • It often appears as a slow-growing, irregularly pigmented lesion, primarily on the face.
  • Progression to invasive melanoma is estimated to occur in 2-5% of cases.

Purpose of the Study:

  • To review clinical and histopathological findings aiding lentigo maligna diagnosis.
  • To examine current treatment strategies for lentigo maligna, emphasizing surgical approaches.

Main Methods:

  • Review of clinical presentations of lentigo maligna.
  • Analysis of histopathological diagnostic criteria.
  • Evaluation of surgical treatment options and their outcomes.

Main Results:

  • Diagnosis can be challenging, particularly in early or atypical presentations.
  • Lesion location and size pose significant challenges for surgical treatment, impacting cosmetic and functional results.
  • Surgical interventions are a primary focus for management.

Conclusions:

  • Accurate diagnosis relies on careful evaluation of clinical and histopathological features.
  • Treatment decisions must balance efficacy with the potential for cosmetic compromise.
  • Further research may refine diagnostic and therapeutic strategies for lentigo maligna.