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Shake it off: A curious case of rigors
Shannon Han1, Sherin John2, Christopher D Jackson1
1Department of Medicine, Division of General Internal Medicine, Assistant Dean of Student Affairs, UTHSC COM, Senior Associate Program Director, University of Tennessee Health Science Center, Internal Medicine Residency, 920 Madison Ave, Suite 531, Memphis, TN 38163, USA.
Heparin-induced anaphylactoid reactions are rare but serious systemic responses to heparin. This case highlights an isolated reaction without heparin-induced thrombocytopenia (HIT), emphasizing prompt diagnosis and heparin cessation for patient safety.
Area of Science:
- Immunology
- Hematology
- Pharmacology
Background:
- Heparin-induced anaphylactoid reactions (HIAR) are rare systemic events linked to heparin exposure.
- The precise mechanism of HIAR remains unclear, but platelet activation and anti-platelet factor 4 antibodies are implicated.
- HIAR shares immunological links with heparin-induced thrombocytopenia (HIT), involving anti-platelet factor 4 antibodies.
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