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Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Aug 2, 2025

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

Published on: August 15, 2019

Mouse models for immuno-oncology.

Marcus Bosenberg¹, Edison T Liu², Chun I Yu²

¹Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.

Trends in Cancer

|April 22, 2023

Summary

This summary is machine-generated.

Understanding in vivo mechanisms is crucial for advancing cancer immunotherapy. Preclinical mouse models are vital for studying treatment responses and toxicities, but require further development.

Keywords:

cancer immunotherapy collaborative cross mice diversity outbred mice genetically engineered mice humanized mice mouse model

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Last Updated: Aug 2, 2025

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

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Published on: August 15, 2019

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Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

Area of Science:

Immunology
Oncology
Preclinical Research

Background:

Clinical success of cancer immunotherapy is limited by incomplete understanding of in vivo treatment response and toxicity mechanisms.
Effective preclinical models are essential to bridge this knowledge gap for advancing cancer immunotherapy.

Purpose of the Study:

To review the advantages and limitations of current in vivo preclinical models for cancer immunotherapy research.
To discuss future developments in preclinical model systems for immunotherapy.

Main Methods:

Literature review and discussion of existing preclinical in vivo model systems.
Analysis of mouse models commonly used in cancer immunotherapy research.

Main Results:

Mice are frequently utilized in basic and translational research for immune interventions in cancer.
Current models offer benefits but also possess limitations that need addressing for improved immunotherapy development.

Conclusions:

Further development of preclinical in vivo models is necessary to overcome challenges in clinical cancer immunotherapy.
Advanced model systems are key to realizing the full clinical potential of cancer treatments targeting the immune system.