Related Experiment Video
Updated: Aug 2, 2025

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
Published on: August 30, 2011
Semantic Priming from Uncued Distractors in Alzheimer's Disease
Julie A Higgins1, William Milberg2,3, Regina McGlinchey2,3
1Division of Social Sciences and Communications, Manhattanville College, Purchase, New York, USA.
Research Question:
Are semantic impairments in Alzheimer's disease (AD) partially due to deficits in spatial attention?
Methods And Results:
In a target detection task, both older adults (OAs) and AD individuals were facilitated by valid spatial cues, but only OAs were impaired by invalid cues compared to neutral. In a reading task, spatial cues validly or invalidly cued the location of pictures, which were related or unrelated to subsequent, centrally presented, words. OAs showed semantic priming only after valid cues, whereas AD individuals showed priming after valid and invalid cues.
Discussion:
Failure to inhibit uncued locations results in processing of potentially distracting semantic information in AD.
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