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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
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Massive Neonatal Arterial Ischemic Stroke.

Gemma Arca1, Christian Núñez2, Christian Stephan-Otto3

  • 1Department of Neonatology, Hospital Clínic, IDIBAPS, Barcelona, Spain; NeNe Foundation, Madrid, Spain.

Pediatric Neurology
|April 23, 2023
PubMed
Summary
This summary is machine-generated.

Massive neonatal arterial ischemic stroke (M-NAIS) is a severe condition in newborns with significant brain swelling. Identifying M-NAIS early can lead to better rehabilitation and prognosis for affected infants.

Keywords:
Brain midline shiftEdemaMassive infarction volumeNeonatal arterial ischemic stroke

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Area of Science:

  • Neurology
  • Neonatal Medicine
  • Pediatric Stroke

Background:

  • Massive infarction in adults causes severe brain swelling.
  • The existence and implications of a similar condition in neonates were unexplored.

Purpose of the Study:

  • To identify massive neonatal arterial ischemic stroke (M-NAIS).
  • To assess the clinical implications of M-NAIS in neonates.

Main Methods:

  • Prospective multicenter cohort study of 48 neonates with middle cerebral artery (MCA) NAIS.
  • MRI within 3 days of symptom onset to detect space-occupying mass effect.
  • Neurodevelopmental assessment at 24 months.

Main Results:

  • 31% of neonates (15/48) showed signs of M-NAIS.
  • M-NAIS cases had significantly larger infarct volumes (29% vs 4.9%).
  • M-NAIS was associated with earlier, longer seizures and severe neurodevelopmental outcomes (79% vs 6%).

Conclusions:

  • M-NAIS is a distinct subtype of neonatal stroke with characteristic imaging findings.
  • Neonates with M-NAIS frequently experience adverse neurodevelopmental outcomes.
  • Early identification of M-NAIS is crucial for timely interventions and accurate prognostication.