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Obesity and the obesity paradox in patients with severe COVID-19
John Jaime Sprockel Díaz1, Victoria Eugenia Coral Zuñiga2, Eliana Angarita Gonzalez2
1Internal Medicine Department, Hospital San Jose (San Jose Hospital), Bogota, Colombia; Fundacion Universitaria De Ciencias De La Salud (University Foundation of Health Sciences), Bogota, Colombia; Intensive Care Unit of El Tunal Hospital - Comprehensive Health Services Southern Sub-network (Unidad de Cuidados Intensivos del Hospital El Tunal - Subred Integrada de Servicios de Salud del Sur), Bogota, Colombia.
Objective:
To test the presence of the obesity paradox in two cohorts of patients hospitalized for COVID-19.
Design:
Two multicenter prospective cohorts.
Setting:
Three fourth level institutions.
Patients:
Adults hospitalized in the general ward for confirmed COVID-19 in the three institutions and those admitted to one of the 9 critical care units of one of the institutions.
Interventions:
None.
Main Variables Of Interest:
Categorized weight and its relationship with admission to the ICU in hospitalized patients and death in the ICU.
Result:
Of 402 hospitalized patients, 30.1% were obese. Of these, 36.1% were admitted to the ICU vs. 27.1% of non-obese patients. Of the 302 ICU patients, 46.4% were obese. Of these, mortality was 45.0% vs. 52.5% for non-obese. The requirement to transfer hospitalized patients to the ICU admission get a HR of 1.47 (95%CI 0.87-2.51, p = 0.154) in the multivariate analysis. In intensive care patients, an HR of 0.99 (95%CI: 0.92-1.07, p = 0.806) was obtained to the association of obesity with mortality.
Conclusions:
The present study does not demonstrate an association between obesity and risk of inpatient transfer to intensive care or death of intensive care patients due to COVID-19 therefore, the presence of an obesity paradox is not confirmed.
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