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Updated: Aug 1, 2025
Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
Published on: November 28, 2015
Advances in research on immune escape mechanism of glioma
1Department of Neurosurgery, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, China.
Background:
Glioma is the most common primary intracranial malignancy in clinical practice, and in particular, IDH-wildtype glioblastoma has the worst prognosis. In recent years, surgical resection combined with simultaneous radiotherapy and immune checkpoint inhibitors has made some progress, but the efficacy is still not satisfactory, which may be related to the low immunogenicity of glioma cells and the tumor immunosuppressive microenvironment.
Methods:
A comprehensive review of relevant literature was conducted to explore the mechanisms by which tumors suppress antitumor immune responses and produce escape, with a focus on the immune cells in the tumor microenvironment (TME).
Results:
The mechanisms involved in immune evasion of glioma cells are complex and involve with immune cell differentiation and function.
Conclusion:
Our review emphasizes the need for a more profound comprehension of the mechanisms involved in immune response and immune evasion in glioma, to formulate more efficacious treatment modalities.
Insights
Glioma cells evade immune detection through complex mechanisms within the tumor microenvironment (TME). Understanding these immune evasion strategies is crucial for developing effective glioma treatments.
Area of Science:
- Neuro-oncology
- Immunology
- Cancer Biology
Background:
- Glioma, particularly IDH-wildtype glioblastoma, is a common and aggressive brain tumor with poor prognosis.
- Current treatments like surgery, radiotherapy, and immune checkpoint inhibitors show limited efficacy due to low tumor immunogenicity and immunosuppressive microenvironments.
Purpose of the Study:
- To explore the intricate mechanisms of tumor immune evasion in glioma.
- To identify key immune cells and their roles within the tumor microenvironment (TME) that contribute to immune suppression.
Main Methods:
- A comprehensive literature review was performed.
- Focused on analyzing mechanisms of immune suppression and escape employed by tumors.
- Specifically investigated the role of immune cells within the glioma TME.
Main Results:
- Glioma immune evasion involves complex interactions and functions of immune cells.
- The tumor microenvironment (TME) plays a critical role in modulating immune responses against glioma.
Conclusions:
- A deeper understanding of glioma immune response and evasion mechanisms is essential.
- This knowledge is vital for developing more effective therapeutic strategies against glioma.
