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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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Related Experiment Video

Updated: Aug 1, 2025

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication
14:52

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Published on: December 11, 2013

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Correlation between ankle-brachial index and subtle cognitive decline.

Hui-Feng Guo1, Yi Wu2, Guo-Xiang Fu3

  • 1Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, P. R. China.

Brain and Behavior
|April 24, 2023
PubMed
Summary
This summary is machine-generated.

The ankle-brachial index (ABI) is significantly associated with subtle cognitive decline (SCD), a potential early stage of Alzheimer's disease. Low ABI may predict early cognitive impairment, highlighting its clinical significance for AD prevention.

Keywords:
Alzheimer's diseaseankle-brachial indexcorrelationsubtle cognitive decline

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Area of Science:

  • Neurology
  • Cardiovascular Health
  • Geriatrics

Background:

  • Subtle cognitive decline (SCD) represents an early stage of Alzheimer's disease (AD).
  • The ankle-brachial index (ABI) is linked to cognitive impairment, but its association with SCD requires further investigation.

Purpose of the Study:

  • To investigate the relationship between ABI and SCD.
  • To determine if ABI can serve as a predictor for early cognitive decline.

Main Methods:

  • A cohort of 217 patients with SCD and 259 controls underwent cognitive function testing.
  • Logistic regression and Pearson's correlation analyses were used to assess the association between ABI and cognitive decline.

Main Results:

  • Significant differences in age, comorbidities (hypertension, diabetes), and ABI were observed between SCD and control groups.
  • ABI was independently associated with cognitive decline after adjusting for confounding factors.
  • A low ABI (<0.9) significantly impacted memory and visual-spatial cognitive domains.

Conclusions:

  • ABI is significantly associated with SCD.
  • ABI may be a critical tool for predicting early cognitive decline and Alzheimer's disease.