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[Mammalian DMRTs: Structure, function and relationship with cancer]

Hai-Long Li1, Zi-Cong Zou1, Chi Fang1

  • 1Department of Clinical Medicine, College of Medicine, Zhengzhou University, Zhengzhou 450001, China.

Sheng Li Xue Bao : [Acta Physiologica Sinica]
|April 24, 2023
PubMed

Insights

The DMRT gene family, crucial for sexual determination and organ development, also plays a role in cancer. Research highlights DMRT genes as potential targets for tumor formation and therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • The DMRT gene family encodes transcription factors with a conserved DM domain, essential for DNA binding and regulation.
  • These genes are critical for sexual determination and the development of both sexual and extrasexual organs.
  • Emerging evidence links DMRT genes to the development and progression of various cancers.

Approach:

  • This review synthesizes current research on mammalian DMRT genes, focusing on their structure and function.
  • It examines the involvement of DMRTs in cancer development, progression, and potential therapeutic applications.
  • The review primarily considers studies in human and mouse models.

Key Points:

  • DMRTs regulate DNA and are vital for sexual differentiation, gonadal, and germ cell development.
  • They also influence extrasexual organ development, including the nervous and musculoskeletal systems.
  • DMRTs are implicated in cancers such as prostate, breast, and lung cancer.

Conclusions:

  • Mammalian DMRT genes exhibit diverse roles beyond sexual determination, impacting organogenesis and disease.
  • Their involvement in cancer progression suggests potential as biomarkers and therapeutic targets.
  • Further investigation into DMRT genes could yield novel strategies for cancer treatment.

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