Related Experiment Video For PGC- 1α
Updated: Aug 1, 2025

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
Published on: March 18, 2022
PGC-1α in osteoarthritic chondrocytes: From mechanism to target of action
Haochen Wang1, Jianbang Su1, Minghao Yu1
1Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, China.
Abstract:
Osteoarthritis (OA) is one of the most common degenerative joint diseases, often involving the entire joint. The degeneration of articular cartilage is an important feature of OA, and there is growing evidence that the mitochondrial biogenesis master regulator peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) exert a chondroprotective effect. PGC-1α delays the development and progression of OA by affecting mitochondrial biogenesis, oxidative stress, mitophagy and mitochondrial DNA (mtDNA) replication in chondrocytes. In addition, PGC-1α can regulate the metabolic abnormalities of OA chondrocytes and inhibit chondrocyte apoptosis. In this paper, we review the regulatory mechanisms of PGC-1α and its effects on OA chondrocytes, and introduce potential drugs and novel nanohybrid for the treatment of OA which act by affecting the activity of PGC-1α. This information will help to further elucidate the pathogenesis of OA and provide new ideas for the development of therapeutic strategies for OA.
Related Concept Videos
GPCRs Regulate Adenylyl Cylase Activity
GPCR Desensitization
G-Protein Gated Ion Channels
Sensory...
Activation and Inactivation of G Proteins
cAMP-dependent Protein Kinase Pathways
Transducer Mechanism: G Protein–Coupled Receptors
GPCRs are also called heptahelical,...

