Related Experiment Video
Updated: Aug 1, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Learning on Arbitrary Graph Topologies via Predictive Coding
Tommaso Salvatori1, Luca Pinchetti1, Beren Millidge2
1Department of Computer Science, University of Oxford, UK.
Abstract:
Training with backpropagation (BP) in standard deep learning consists of two main steps: a forward pass that maps a data point to its prediction, and a backward pass that propagates the error of this prediction back through the network. This process is highly effective when the goal is to minimize a specific objective function. However, it does not allow training on networks with cyclic or backward connections. This is an obstacle to reaching brain-like capabilities, as the highly complex heterarchical structure of the neural connections in the neocortex are potentially fundamental for its effectiveness. In this paper, we show how predictive coding (PC), a theory of information processing in the cortex, can be used to perform inference and learning on arbitrary graph topologies. We experimentally show how this formulation, called PC graphs, can be used to flexibly perform different tasks with the same network by simply stimulating specific neurons. This enables the model to be queried on stimuli with different structures, such as partial images, images with labels, or images without labels. We conclude by investigating how the topology of the graph influences the final performance, and comparing against simple baselines trained with BP.
Related Concept Videos
Associative Learning
Classical conditioning, also known...
Introduction to Learning
In contrast to learned behaviors, unlearned behaviors such as crying, sexual...
Observational Learning
Cognitive Learning
E. C. Tolman's theory of purposive behavior emphasizes that much behavior is goal-directed. He argued that to understand behavior, we must look at the entire sequence of actions leading to a goal. For instance, high school students study hard, not just due to past reinforcement but also to achieve the goal of getting into a good college.
Tolman introduced the idea that behavior is influenced by...
End Point Prediction: Gran Plot
For potentiometric titration, the Gran plot is created by plotting...
Neural Circuits
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...

