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Recent clinical trials with stem cells to slow or reverse normal aging processes

Ricardo P Garay1,2

  • 1Pharmacology and Therapeutics, Craven, 91360 Villemoisson-sur-Orge, France.

Frontiers in Aging
|April 24, 2023
PubMed

Insights

Mesenchymal stem cell therapies show promise for physical frailty and facial skin aging. Clinical trials are ongoing, with early results suggesting potential benefits for healthy life expectancy and tissue regeneration.

Area of Science:

  • Gerontology and Regenerative Medicine
  • Stem Cell Biology and Therapeutics

Background:

  • Aging diminishes stem cell regenerative capacity, prompting research into stem cell interventions.
  • Mesenchymal stem cell (MSC) therapies are being investigated to combat age-related conditions.
  • Clinical trials are evaluating MSC efficacy for physical frailty and facial skin aging.

Purpose of the Study:

  • To review current clinical trials on mesenchymal stem cell interventions for aging conditions.
  • To assess the efficacy and safety of MSCs in treating physical frailty and facial skin aging.
  • To understand the complementary nature of research in these two aging areas.

Main Methods:

  • Systematic extraction of data from national and international clinical trial databases (US, EU, China, Japan, WHO).
  • Analysis of ongoing and completed clinical trials for physical frailty and facial skin aging.
  • Review of reported outcomes for specific MSC preparations (Lomecel-B, umbilical cord-derived MSCs, adipose-derived MSCs).

Main Results:

  • Positive phase II results for intravenous Lomecel-B in physical frailty.
  • Completion of a phase I/II study for umbilical cord-derived MSCs in physical frailty.
  • Positive results for autologous adipose-derived stem cells in facial skin aging.
  • Sixteen additional clinical trials are currently active for these conditions.

Conclusions:

  • Mesenchymal stem cell interventions show potential for improving healthy life expectancy and public health outcomes in physical frailty.
  • Research into facial skin aging using MSCs offers insights into tissue regeneration.
  • Investigating both physical frailty and skin aging provides a comprehensive view of MSC therapeutic potential in aging.
Keywords:
agingclinical trialfrailtylomecel-Bmesenchymal stem cellsrejuvenationskin agingstem cells

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