GC-MS based metabolite profiling, antioxidant and antiurolithiatic properties of apple cider vinegar
Ankul S Singh1, Anuragh Singh1, Chitra Vellapandian1
1Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, 603203, India.
Aim:
To perform in vitro analysis of antioxidant and antiurolithiasis to carry out GC-MS-based metabolite profile.
Materials & Methods:
The effect of apple cider vinegar (ACV) in vitro, antioxidant and GC-MS analysis was evaluated. The antioxidant studies were performed. In vitro techniques included nucleation, aggregation and growth assay.
Results & Conclusion:
The presence of polyphenols, flavonoids, alkaloids and carbohydrates was shown. Concentrations from 5-30 μg/ml could dissolve calcium oxalate (p < 0.05) in vitro. The IC50 value of ACV in DPPH was found to be around 7 μg/ml and the IC50 value of the ACV in ABTS assay was around 9 μg/ml. Different phytocompounds were obtained from GC-MS analysis. ACV can be consumed to prevent kidney stones which seems helpful to the current therapy.
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