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Related Experiment Video

Updated: Aug 1, 2025

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Cortical microstructural associations with CSF amyloid and pTau.

Talia M Nir¹, Julio E Villalón-Reina¹, Lauren Salminen¹

¹Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, United States.

Medrxiv : the Preprint Server for Health Sciences

|April 24, 2023

Summary

Diffusion MRI (dMRI) reveals microstructural brain changes linked to Alzheimer's disease (AD) biomarkers. These advanced imaging techniques show promise in detecting early AD pathology and cognitive decline.

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Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images

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Published on: November 20, 2015

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Last Updated: Aug 1, 2025

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Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images

Published on: November 20, 2015

Area of Science:

Neuroimaging
Biomarkers
Neurodegenerative Diseases

Background:

Alzheimer's disease (AD) pathology begins in cortical gray matter.
Multi-shell diffusion MRI (dMRI) models like NODDI and MAP-MRI offer advanced insights into brain microstructure.
Few studies have evaluated these dMRI models in the context of early AD changes.

Conclusions:

Cortical dMRI measures reflect early AD-related microstructural changes.
dMRI may offer a sensitive tool for understanding AD pathogenesis and cognitive decline.
dMRI provides complementary information to cortical thickness in assessing AD.