Pancreatic Malakoplakia: A Rare Pathology Associated With Acute Pancreatitis

Area of Science:

• Gastroenterology
• Pathology
• Oncology

Background:

• Malakoplakia is a rare inflammatory condition characterized by granulomatous tumor-like lesions.
• It most commonly affects the genitourinary system, particularly in immunosuppressed individuals.
• The gastrointestinal tract is the second most frequent site, typically involving the colon.

Observation:

• This report details an unusual case of malakoplakia manifesting as a pancreatic mass.
• Initial imaging suggested an infiltrating tumor in the pancreatic tail and greater curvature.
• Endoscopic ultrasound-guided biopsy confirmed the diagnosis of malakoplakia.

Findings:

• The pancreatic mass was diagnosed as malakoplakia, an uncommon presentation.
• The condition was successfully managed with antibiotic therapy.
• This case expands the known spectrum of malakoplakia manifestations.

Implications:

• Highlights the importance of considering malakoplakia in the differential diagnosis of pancreatic masses, even in rare presentations.
• Demonstrates the efficacy of antibiotic treatment for malakoplakia in the pancreas.
• Underscores the need for thorough investigation and biopsy in suspected pancreatic lesions.