Related Experiment Video

Updated: Aug 1, 2025

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
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Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

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Tacrolimus for the Management of Delayed Onset and Treatment-Refractory Immune-Related Hepatitis

Vinny Ea1, Natalie L Y Ngu2, Hock W Kua3

  • 1Department of Gastroenterology and Hepatology, Monash Health, Melbourne, Australia.

ACG Case Reports Journal
|April 24, 2023
PubMed

Immune checkpoint inhibitors, such as pembrolizumab, are effective in the management of metastatic malignancies, such as melanoma, and are associated with a spectrum of immune-related organ toxicities, including immune-related hepatitis (ir-hepatitis). The clinical presentation of ir-hepatitis varies in onset and severity, and management involves immunosuppression with corticosteroids and mycophenolate mofetil as first and second-line agents. Several agents have been proposed as third-line options for treatment-refractory disease. We report the successful use of tacrolimus for delayed onset and treatment-refractory ir-hepatitis secondary to pembrolizumab.

Keywords:
hepatitisimmune checkpoint inhibitorimmune-related adverse eventspembrolizumabtacrolimus

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