ESHRE PGT Consortium data collection XXI: PGT analyses in 2018.
F Spinella1, F Bronet2, F Carvalho3,4
1Eurofins GENOMA Group srl, Molecular Genetics Laboratories, Rome, Italy.
Human Reproduction Open
|April 24, 2023
Summary
Preimplantation genetic testing (PGT) trends show increased trophectoderm biopsy and comprehensive testing for PGT-A. However, single-cell testing persists for PGT-M and PGT-SR, indicating evolving diagnostic strategies.
Area of Science:
- Reproductive Medicine
- Genetics
- Embryology
Background:
- The European Society of Human Reproduction and Embryology (ESHRE) PGT Consortium has collected data since 1997.
- Previous publications include 20 datasets and a 10-year overview of PGT practices.
Purpose of the Study:
- To analyze trends and developments in preimplantation genetic testing (PGT) in 2018.
- To compare 2018 PGT practices with previous years.
Main Methods:
- Data collected voluntarily from 44 PGT centers for analyses performed in 2018.
- Included biopsy method, diagnostic technology, and clinical outcomes.
- Excluded inconsistent data; analyzed transfers within 2 years for cumulative pregnancy rates.
Main Results:
- Blastocyst biopsy increased for PGT-M (33%) and is standard for PGT-A (98%) and concurrent PGT-M/SR/A (96%).
- Comprehensive whole-genome amplification (WGA) testing dominated PGT-A (98%) and concurrent PGT-M/SR/A (74-98%).
- Single-cell testing with PCR/FISH remains prevalent for PGT-M (88%) and PGT-SR (56%).
Conclusions:
- Trophectoderm biopsy and comprehensive testing correlate with higher diagnostic efficiency and better outcomes.
- ESHRE PGT Consortium datasets are valuable for tracking PGT practice evolution.
- Findings represent data from 44 centers and not global trends; infant health data were not included.
Keywords:
PGTaneuploidycomprehensive genetic testingdata collectionhuman embryomonogenic disordersregistrystructural rearrangementsMore Related Videos
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