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Published on: October 4, 2021
Lamotrigine-Associated Progressive Dysphasia and Cognitive Dysfunction
Joshua C Brown1,2, Jessica L Broadway2
1Warren Alpert Medical School of Brown University, 345 Blackstone Blvd, Providence, RI, USA.
Abstract:
Lamotrigine is generally accepted as a well-tolerated medication with few cognitive side effects. Here, we report a case of a 62-year old female with a severe, rapidly progressive dementia-like process which was completely reversed after reduction of lamotrigine. Associated findings included hyperreflexia with clonus, ataxia, Wernicke-like dysphasia, global cognitive impairment, burst suppression on electroencephalogram (EEG), and bilateral parietal hypo-metabolism on fluorodeoxyglucose-Positron Emission Tomography (FDG-PET). To our knowledge, this is the first case of a severe neuropsychiatric syndrome attributed to lamotrigine at the Food and Drug administration (FDA) recommended dose and not associated with epileptic activity.
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