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What Kept Back on the Mirror of COVID-19-Related Acute Transverse Myelitis? A Genetic Background!
Reza Sinaei1,2, Sara Pezeshki2,3, Roya Sinaei1,4
1Department of Pediatrics, Kerman University of Medical Sciences, Kerman, Iran.
Abstract:
COVID-19-associated acute transverse myelitis (ATM) cases have been reported worldwide. Nevertheless, Iran, Italy, and the USA are the most affected countries, witnessing the possibility that genetic factors might be associated with this susceptibility. The genetic variants of the coronavirus-2 entry mechanisms and host innate immune response-related genes like interferons, interleukins, Toll-like receptors, human leukocyte antigens, blood groups, and some risk loci may be accountable. This study describes the compatibility of the geographical distribution between ATM and the Neanderthal core haplotype that confers risk for severe COVID-19 and some possible culprit genes.
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