Related Experiment Video

Updated: Aug 1, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.4K

Sudden death in ischemic heart disease: looking for new predictors: polygenic risk

Alessandro Boccanelli1, Angela Beatrice Scardovi2

  • 1Department of Cardiology, Quisisana Hospital and Clinics, Rome.

European Heart Journal Supplements : Journal of the European Society of Cardiology
|April 24, 2023
PubMed

Insights

Genetic risk scores can identify individuals at higher risk for sudden death (SD) even without current guideline indications. The genome-wide polygenic score for coronary artery disease (GPSCAD) helps stratify risk in stable coronary artery disease patients.

Area of Science:

  • Cardiology
  • Genetics
  • Preventive Medicine

Background:

  • Sudden death (SD) frequently affects individuals not meeting current defibrillator implantation guidelines.
  • Polygenic inheritance, involving common genetic variations (polymorphisms), contributes to inherited risk.
  • Identifying at-risk individuals in primary prevention is crucial for effective intervention.

Purpose of the Study:

  • To assess the utility of the genome-wide polygenic score for coronary artery disease (GPSCAD) in stratifying SD risk.
  • To determine if biological markers and electrocardiogram can identify individuals at higher risk for SD.
  • To evaluate GPSCAD's role in intermediate-risk populations with stable coronary artery disease.

Main Methods:

  • The PRE-DETERMINE cohort study investigated GPSCAD in patients with stable coronary artery disease.
  • Risk stratification was performed on individuals without severe systolic dysfunction or defibrillator indication.
  • A mean follow-up of 8.0 years was conducted to assess outcomes.

Main Results:

  • Patients in the top decile of GPSCAD exhibited significantly higher absolute (8.0% vs. 4.8%) and relative (29% vs. 16%) risks of SD.
  • No association was found between the highest GPSCAD decile and other causes of death (cardiac or non-cardiac).
  • These findings suggest GPSCAD can identify a subset of patients at increased risk for SD.

Conclusions:

  • GPSCAD is a valuable tool for identifying individuals at higher risk of sudden death within a stable coronary artery disease population.
  • The data supports theoretical estimates for defibrillator efficacy and mortality reduction in high-risk patients identified by GPSCAD.
  • Further research is needed to refine the clinical application of GPSCAD in primary prevention strategies.

Keywords:
Chronic coronary artery diseaseGenome-wide polygenic scoreSudden death

More Related Videos

Implantation of Electroencephalogram and Electrocardiogram Telemetry Devices in Neonatal Rabbit Kits06:46

Implantation of Electroencephalogram and Electrocardiogram Telemetry Devices in Neonatal Rabbit Kits

Published on: February 28, 2025

355
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.4K

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
39
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.4K
Polygenic Traits01:18

Polygenic Traits

When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
66.1K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
129
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.7K
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
15