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Studying Cavitation Enhanced Therapy
Published on: April 9, 2021
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Association between Serum Cys C and PTB Cavitation.
Shumin Tan1, Duochi Wu1, Yeying Wu1
1Department of Clinical Laboratory, Haikou City People's Hospital, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South University, Haikou, Hainan, China.
Disease Markers
|April 24, 2023
Summary
Elevated cystatin C (Cys C) levels are linked to pulmonary tuberculosis (PTB) with cavitation. This finding suggests Cys C may play a role in PTB disease progression and cavity formation.
Area of Science:
- Biochemistry
- Immunology
- Infectious Diseases
Background:
- Cystatin C (Cys C) influences immune responses and protease-antiprotease balance.
- Imbalance in protease and antiprotease activity is implicated in infectious diseases.
- The specific role of Cys C in pulmonary tuberculosis (PTB) and cavitation remains unclear.
Purpose of the Study:
- To investigate the association between serum Cys C levels and the presence of cavitation in PTB patients.
- To determine if Cys C is a potential biomarker for PTB-related lung destruction.
Main Methods:
- Retrospective study including cavitary PTB patients, noncavitary PTB patients, and healthy controls.
- Measurement of serum Cys C, CRP, BUN, UA, and CR.
- Statistical analysis using Kruskal-Wallis, Spearman rank correlation, and binary logistic regression.
Main Results:
- Cavitary PTB patients exhibited significantly higher serum Cys C levels compared to noncavitary PTB patients and healthy controls (p=0.022).
- Serum Cys C levels correlated positively with serum BUN and CR concentrations in PTB patients.
- Elevated serum Cys C was independently associated with pulmonary cavitation in PTB patients (OR=1.426).
Conclusions:
- Elevated serum Cys C levels are significantly associated with pulmonary cavitation in PTB.
- Cys C may serve as a potential biomarker for assessing disease severity and cavitation in PTB.
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