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Updated: Aug 1, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Preliminary observation of thyroid function changes in subclinical thyroid diseases.

Hua-Xin Wang¹, Wen-Yu Gao¹, Yang Yang¹

¹Clinical Laboratory, Huanghua Boai Hospital, Cangzhou, Hebei, China.

Technology and Health Care : Official Journal of the European Society for Engineering and Medicine

|April 24, 2023

Summary

Subclinical thyroid diseases, affecting millions, are often hard to diagnose. Hypothyroidism Ia and hyperthyroidism Ia show higher rates of normalization, suggesting specific TSH ranges are crucial for effective diagnosis and treatment.

Keywords:

Subclinical hyperthyroidism diagnostic grading odds ratio prognosis subclinical hypothyroidism

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Last Updated: Aug 1, 2025

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Area of Science:

Endocrinology
Clinical Medicine
Thyroidology

Background:

Subclinical thyroid diseases affect 1.95% and 5.55% of adults in China.
These conditions present diagnostic and therapeutic challenges.

Purpose of the Study:

To investigate the development and prognosis of subclinical thyroid diseases.
To provide a single-center experience for clinical reference.

Main Methods:

Retrospective analysis of 240 cases from April 2019 to August 2021.
Binary logistic regression used to determine odds ratios for normalization.

Main Results:

Hypothyroidism Ia and hyperthyroidism Ia were most common types to normalize (P<0.001).
Normalized patients had significantly lower TSH levels (P=0.015).
Hypothyroidism Ia (OR 3.138) and hyperthyroidism Ia (OR 2.659) showed higher odds of normalization compared to hyperthyroidism Ib.

Conclusions:

Subclinical hypothyroidism Ia and hyperthyroidism Ia demonstrate a greater likelihood of reverting to normal states.
Further exploration of TSH reference ranges is recommended for improved diagnosis and treatment strategies.