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Related Concept Videos

Cardiac Catheterization III: Left Heart Catheterization01:24

Cardiac Catheterization III: Left Heart Catheterization

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Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
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Cardiac Catheterization II: Right Heart Catheterization01:21

Cardiac Catheterization II: Right Heart Catheterization

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Right Heart Catheterization: An OverviewRight heart catheterization is an invasive diagnostic procedure that measures right-sided cardiac and pulmonary artery pressures, calculates cardiac output, and identifies intracardiac shunts. It provides detailed hemodynamic data essential for diagnosing and managing various cardiovascular conditions, such as pulmonary hypertension.Access SitesCommon access sites for right heart catheterization include the internal jugular vein in the neck region, the...
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Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

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Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
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Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

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Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
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Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

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Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
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Transcatheter left ventriculoplasty.

Nikolaos Spilias1, Travis M Howard1, Chris M Anthony1

  • 1Heart, Vascular & Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.

Eurointervention : Journal of Europcr in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
|April 24, 2023
PubMed
Summary
This summary is machine-generated.

Novel device-based therapies are emerging to address heart failure with reduced ejection fraction (HFrEF). Left ventriculoplasty aims to reshape the left ventricle, offering a new approach to reverse remodelling and improve outcomes.

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Area of Science:

  • Cardiology and Cardiovascular Interventions
  • Medical Device Technology
  • Heart Failure Pathophysiology

Background:

  • Heart failure with reduced ejection fraction (HFrEF) remains a significant clinical challenge despite advances in conventional therapies.
  • Left ventricular remodelling and dilatation are key pathological features associated with poor prognosis in heart failure.
  • A substantial treatment gap exists for advanced heart failure, necessitating innovative therapeutic strategies.

Approach:

  • This review explores the rationale and historical context of left ventriculoplasty as a therapeutic intervention for heart failure.
  • It examines novel minimally invasive, device-based approaches targeting left ventricular geometry and reverse remodelling.
  • The review discusses current pivotal clinical trials investigating transcatheter left ventriculoplasty devices in the US.

Key Points:

  • Left ventriculoplasty offers a device-based strategy to directly address left ventricular remodelling in heart failure.
  • Minimally invasive structural heart interventions represent a new frontier in managing heart failure.
  • Two novel left ventriculoplasty devices are currently undergoing investigation in major clinical trials.

Conclusions:

  • Interventional heart failure therapy, including left ventriculoplasty, is a rapidly developing field.
  • Device-based left ventriculoplasty holds promise for improving outcomes in patients with HFrEF.
  • Potential challenges in the clinical adoption of these novel device therapies warrant careful consideration.