Related Experiment Video
Updated: Aug 1, 2025
04:16
Whole Body Vibration Methods with Survivors of Polio
Published on: October 17, 2018
8.8K
Post-Polio Syndrome Revisited
Michael Punsoni1, Nelli S Lakis1, Michelle Mellion1
1Division of Neuropathology, Departments of Pathology and Laboratory Medicine, Neurology, and Neurosurgery, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USA.
Neurology International
|April 24, 2023
Summary
Post-polio syndrome (PPS) causes new or worsening motor neuron symptoms years after polio. This case study differentiates PPS from amyotrophic lateral sclerosis (ALS) based on distinct histopathologic features.
Area of Science:
- Neurology
- Virology
- Pathology
Background:
- Post-polio syndrome (PPS) affects 25-40% of polio survivors, presenting decades after initial infection.
- PPS symptoms mimic motor neuron diseases (MNDs) like amyotrophic lateral sclerosis (ALS).
- This occurs due to the selective degeneration or death of motor neurons in the brainstem and spinal cord.
Observation:
- A case of PPS in a 68-year-old man is presented.
- The patient had a history of bulbar and cervical cord involvement from poliomyelitis.
- The study reviews relevant literature on PPS and ALS.
Findings:
- The case highlights the diagnostic challenge of differentiating PPS from ALS.
- Salient histopathologic features distinguishing PPS from ALS are contrasted.
- This differentiation is crucial for accurate diagnosis and management.
Implications:
- Understanding the distinct pathology of PPS is vital for patient care.
- Improved diagnostic criteria can prevent misdiagnosis of PPS as ALS.
- Further research into the long-term effects of poliovirus infection is warranted.
More Related Videos
Related Concept Videos
01:23Peripheral Artery Disease V: Postoperative Nursing Management
14
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
14
01:15Parkinson's Disease: Overview
625
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
625
01:30Peripheral Artery Disease I: Introduction
12
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
12
01:26Peripheral Artery Disease IV: Nursing Management
15
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
15
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
20
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
20
01:24Parkinson's Disease: Treatment
315
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
315