Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Propagation of Action Potentials

Propagation of Action Potentials

The propagation of an action potential refers to the process by which a nerve impulse, or "action potential," travels along a neuron.
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...

Action Potential

Action Potential

Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they...

Generation of Action Potential in Skeletal Muscles

Generation of Action Potential in Skeletal Muscles

Every cell in the body maintains a membrane potential due to an uneven distribution of positive and negative charges across its plasma membrane. The membrane potential is measured in millivolts and quantifies the difference in charge across the membrane.
Like neurons, muscle cells are also regarded as excitable due to their capacity to change in response to stimuli, primarily due to voltage-gated ion channels embedded in their plasma membranes, which get activated by alterations in the...

Action Potentials

Action Potentials

Cardiac Action Potential

Cardiac Action Potential

Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials

Action Potential: Phases of Stimulation

Action Potential: Phases of Stimulation

The action potential is a complex electrical event that occurs in excitable cells, such as neurons and muscle cells. It consists of several distinct phases, each with specific characteristics.
Resting Phase:
In this phase, the cell's membrane is at its resting potential, typically around -70 millivolts (mV) for neurons. Inside the cell, there is a higher concentration of potassium ions (K+) and a lower concentration of sodium ions (Na+). Voltage-gated sodium channels are closed, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Comparison of Four Selected Acoustic Measures in Detecting Voice Quality Changes With Botulinum Toxin Treatment in Adductor-Type Laryngeal Dystonia.

American journal of speech-language pathology·2026

Same author

Duration effects on detection cues in simultaneous masking: Analysis using decision variable correlationa).

The Journal of the Acoustical Society of America·2025

Same author

Evidence for the Auditory Nerve Generating Envelope Following Responses When Measured from Eardrum Electrodes.

Journal of the Association for Research in Otolaryngology : JARO·2025

Same author

Human Olivocochlear Effects: A Statistical Detection Approach Applied to the Cochlear Microphonic Evoked by Swept Tones.

Journal of the Association for Research in Otolaryngology : JARO·2024

Same author

Effects of contralateral noise on envelope-following responses, auditory-nerve compound action potentials, and otoacoustic emissions measured simultaneously.

The Journal of the Acoustical Society of America·2024

Same author

Subcortical auditory model including efferent dynamic gain control with inputs from cochlear nucleus and inferior colliculus.

The Journal of the Acoustical Society of America·2023

Search research articles

Related Experiment Video

Updated: Aug 1, 2025

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Published on: June 21, 2022

Computational modeling of the human compound action potential.

Yousef Alamri¹, Skyler G Jennings²

¹Department of Biomedical Engineering, The University of Utah, 390 South, 1530 East, BEHS 1201, Salt Lake City, Utah 84112, USA.

The Journal of the Acoustical Society of America

|April 24, 2023

Summary

This study models the human auditory nerve (AN) compound action potential (CAP) using computational simulations. The models accurately predict human CAPs, aiding auditory disorder research and surgical monitoring.

More Related Videos

Modeling Biological Membranes with Circuit Boards and Measuring Electrical Signals in Axons: Student Laboratory Exercises

Modeling Biological Membranes with Circuit Boards and Measuring Electrical Signals in Axons: Student Laboratory Exercises

Published on: January 18, 2011

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond

Published on: June 24, 2015

Related Experiment Videos

Last Updated: Aug 1, 2025

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Published on: June 21, 2022

Modeling Biological Membranes with Circuit Boards and Measuring Electrical Signals in Axons: Student Laboratory Exercises

Modeling Biological Membranes with Circuit Boards and Measuring Electrical Signals in Axons: Student Laboratory Exercises

Published on: January 18, 2011

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond

Published on: June 24, 2015

Area of Science:

Auditory Neuroscience
Computational Biology
Biomedical Engineering

Background:

The auditory nerve (AN) compound action potential (CAP) is crucial for evaluating auditory function and monitoring the auditory periphery during surgery.
Mathematically, the CAP is understood as the convolution of a unit response (UR) waveform and the firing rate of AN fibers.

Purpose of the Study:

To develop and validate a computational approach for predicting human auditory nerve compound action potentials (CAPs).
To assess the utility of human-based computational models in simulating AN activity for various auditory stimuli.

Main Methods:

Simulated CAPs using human-based computational models of AN activity.
Tested simulations with various stimuli: clicks, chirps, amplitude-modulated carriers, and narrowband CAPs (from noise-masked clicks and tone bursts).
Compared simulated CAPs with experimentally recorded CAPs from human subjects.

Main Results:

Simulations successfully captured many morphological, temporal, and spectral characteristics of human CAPs across all tested stimuli.
The model demonstrated accuracy in predicting CAPs elicited by clicks, chirps, amplitude-modulated carriers, and narrowband noise-masked stimuli.
High fidelity was observed between simulated and empirical CAPs, validating the computational approach.

Conclusions:

Model simulations of human CAPs are effective for refining existing human-based auditory models.
These simulations can assist in designing and analyzing auditory experiments.
The approach holds potential for predicting the impact of hearing loss, synaptopathy, and other auditory disorders on human CAPs.