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Reticulons promote formation of ER-derived double-membrane vesicles that facilitate SARS-CoV-2 replication

Jeffrey M Williams1, Yu-Jie Chen1, Woo Jung Cho2

  • 1Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.

The Journal of Cell Biology
|April 24, 2023
PubMed
Summary

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) hijacks host cell endoplasmic reticulum (ER) proteins, reticulon-3 (RTN3) and RTN4, to build replication organelles. These RTNs are essential for viral replication and infection by SARS-CoV-2 variants.

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