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Solitary rectal ulcer. Electron microscopy study of two cases
Diseases of the Colon and Rectum
|June 1, 1986
Summary
Solitary rectal ulcer syndrome (SRUS) involves rectal ulcers, often caused by trauma and ischemia. Electron microscopy confirmed mucosal fibrosis in two young adult cases.
Area of Science:
- Gastroenterology
- Pathology
Background:
- Solitary rectal ulcer syndrome (SRUS) is a rare disorder.
- It is characterized by a solitary ulcer in the rectum.
Observation:
- Two young adults, an 18-year-old woman and a 24-year-old man, presented with bleeding on defecation, alternating constipation and diarrhea.
- Sigmoidoscopy revealed a solitary rectal ulcer in both patients.
Findings:
- Biopsy analysis confirmed the ulcer through light and electron microscopy.
- Electron microscopy revealed mucosal fibrosis, supporting the proposed pathophysiology of trauma followed by ischemia.
Implications:
- These cases align with the classic presentation and proposed etiology of SRUS.
- The findings highlight the utility of electron microscopy in diagnosing SRUS and understanding its pathogenesis.