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Advances in the expression and function of Fyn in different human tumors

Changqing Liu1, Shan Li1, Yunlian Tang2

  • 1Key Laboratory of Cancer Cellular and Molecular Pathology in Hunan Province, Cancer Research Institute of Hengyang Medical College, University of South China, Hunan Province, 28 Changsheng Road, Hengyang, 421001, People's Republic of China.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|April 24, 2023
PubMed

Insights

The tyrosine kinase Fyn, a SRC family kinase, drives cancer progression. This review details Fyn

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • The tyrosine kinase Fyn is implicated in cancer cell signaling.
  • Fyn's sustained activation correlates with tumor cell migration, proliferation, and metabolism.
  • Fyn expression is observed in various tumor tissues, with diverse roles.

Purpose of the Study:

  • To review recent studies on Fyn's role in human tumors.
  • To focus on Fyn's involvement in melanoma, breast cancer, glioma, lung cancer, and T-cell lymphoma.
  • To provide a foundation for future Fyn-targeted cancer research and therapy.

Main Methods:

  • Literature review of recent studies on Fyn in human cancers.
  • Analysis of Fyn expression patterns and functional roles across different tumor types.
  • Synthesis of findings to highlight Fyn's oncogenic potential.

Main Results:

  • Fyn acts as an oncogene in certain tumors, promoting proliferation and metastasis.
  • Fyn's expression and function are tumor-specific.
  • Evidence links Fyn to key cancer hallmarks like migration and metabolism.

Conclusions:

  • Fyn plays a significant, albeit varied, role in human tumorigenesis.
  • Understanding tumor-specific Fyn functions is crucial for developing targeted therapies.
  • Fyn represents a potential therapeutic target for various cancers.
Keywords:
CancersFynGene regulationOncogeneSRC

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