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Related Experiment Videos

Nausea and vomiting possibly associated with intravenous acyclovir.

S M Lisby, M C Nahata, D A Powell

    Drug Intelligence & Clinical Pharmacy
    |May 1, 1986
    PubMed
    Summary

    Parenteral acyclovir may cause nausea and vomiting in children, a side effect not previously well-documented. Promptly recognizing this adverse drug reaction is crucial for appropriate patient management and avoiding misdiagnosis.

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    Area of Science:

    • Pediatric Pharmacology
    • Adverse Drug Reactions
    • Viral Infections

    Background:

    • Parenteral acyclovir is a common antiviral medication used for serious herpesvirus infections.
    • Nausea and vomiting are not typically listed as common side effects of intravenous acyclovir.
    • Distinguishing drug-induced symptoms from viral illness manifestations is critical in pediatric care.

    Observation:

    • A pediatric patient receiving intravenous acyclovir for recurrent varicella-zoster virus developed significant nausea and vomiting.
    • These symptoms were temporally associated with acyclovir administration and could not be attributed to other causes.
    • Discontinuation of acyclovir led to the complete resolution of nausea and vomiting.

    Findings:

    • This case suggests a potential association between parenteral acyclovir and the development of nausea and vomiting in pediatric patients.
    • The observed adverse effects mimic early symptoms of Reye's syndrome, a serious condition in children with viral infections.
    • Accurate diagnosis is essential to differentiate acyclovir-induced symptoms from other critical conditions.

    Implications:

    • Clinicians should consider nausea and vomiting as potential adverse effects of parenteral acyclovir in children.
    • Early recognition and differentiation from conditions like Reye's syndrome are vital for appropriate management.
    • This case highlights the importance of vigilant monitoring for unexpected side effects of antiviral therapies.

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