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The Brain and Spinal Microvasculature in Normal Aging.

Zin Z Khaing¹, Abarajithan Chandrasekaran¹, Anjali Katta¹

¹Department of Neurological Surgery, University of Washington, Seattle, Washington, USA.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

|April 24, 2023

Summary

Aging alters brain and spinal cord microvasculature, making central nervous system tissue vulnerable to ischemia. This review explores these changes and future research directions for understanding aging

Keywords:

Brain Microvessels Normal aging Spinal cord

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Published on: January 12, 2020

Area of Science:

Neuroscience
Gerontology
Vascular Biology

Background:

Normal aging significantly impacts central nervous system (CNS) microvasculature, increasing susceptibility to ischemic damage.
Aged CNS tissue exhibits heightened sensitivity to ischemic insults due to microvascular alterations.
This review focuses on aging independent of major pathologies like neurodegeneration or vascular disease.

Approach:

Examines age-related changes in brain and spinal cord microvasculature separately.
Discusses emerging technologies for studying CNS microvascular structure and function.
Identifies critical research gaps and future study directions.

Key Points:

Microvascular changes during normal aging render the CNS more vulnerable to ischemia.
Distinct anatomical and physiological differences exist between brain and spinal cord microvasculature.
Advanced technologies are crucial for a deeper understanding of microvascular aging.

Conclusions:

Understanding age-related microvascular alterations is key to mitigating ischemic damage in the CNS.
Further research is needed to address unanswered questions regarding CNS microvascular aging.
Future studies should leverage new technologies to explore microvascular structure and function in aging.