Redefining the Synthetic Logic of Medicinal Chemistry. Photoredox-Catalyzed Reactions as a General Tool for Aliphatic
David F Fernández1,2, María González-Esguevillas1,2, Sebastian Keess1
1Merck Center for Catalysis, Princeton University, Princeton, New Jersey 08544, United States.
Abstract:
C(sp3)-rich aliphatic motifs in drug molecules are strongly associated with clinical success. Historically, the availability of compound libraries based on C(sp3)-rich cores has been limited due to the challenging direct functionalization of aliphatic rings. Instead, most small molecule drug-like libraries are diversified around central aromatic rings. Herein, we present a general approach to the synthesis of diversified libraries featuring aliphatic core rings via photoredox catalysis under mild conditions.
Related Concept Videos
Cycloaddition Reactions: MO Requirements for Photochemical Activation
Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems
Oxidation reactions are fundamental in aromatic carbon-containing systems. An example is the hydroxylation of phenobarbital, a process that transforms it into...
Aldehydes and Ketones to Alkenes: Wittig Reaction Overview
Alkenes via Reductive Coupling of Aldehydes or Ketones: McMurry Reaction
Reactions at the Benzylic Position: Oxidation and Reduction
Vicinal Diols via Reductive Coupling of Aldehydes or Ketones: Pinacol Coupling Overview

![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)
