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Updated: Aug 1, 2025

Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro
Published on: June 6, 2025
[The circular life of viruses]
Alexis Serge Chasseur1, Benoît Muylkens1, Damien Coupeau1
1Virologie moléculaire, Namur Research Institute for Life Sciences (Narilis), Unité de recherche vétérinaire intégrée, université de Namur (UNamur), Namur, Belgique.
Circular RNAs (circRNAs), ancient RNA molecules, play a key role in host-pathogen interactions. Viral circRNAs impact viral and cellular processes, influencing oncogenesis and immune responses.
Area of Science:
- Virology
- RNA Biology
- Molecular Biology
Context:
- Circular RNAs (circRNAs) are increasingly recognized for their roles in biological processes.
- Viral infections can lead to the dysregulation of cellular circRNAs.
- Numerous circRNAs of viral origin have been identified and characterized.
Purpose:
- To explore the multifaceted roles of circular RNAs in host-pathogen interactions.
- To highlight the functional and biogenesis aspects of viral circRNAs.
- To provide an overview of the significance of circRNAs in viral infections.
Summary:
- Circular RNAs (circRNAs), ancient RNA molecules, are integral to host-pathogen relationships.
- Both cellular and viral circRNAs are implicated in viral infections, affecting viral and host cell functions.
- These RNA molecules are involved in virus-induced oncogenesis, immune regulation, and cell differentiation.
Impact:
- Understanding circRNA involvement in viral infections can reveal novel therapeutic targets.
- This research opens new avenues in RNA biology, focusing on the unique properties of circRNAs.
- Highlights the surprising complexity and potential of circRNAs in virology and disease.
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